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Article

Exploring the epigenetic modifications of the RONS-TRPA1-CGRP axis in migraine pathophysiology

1 Sept 2025

Abstract excerpt

BACKGROUND: Epigenetic studies in migraine provided results on the occurrence or lack of epigenetic modifications of genes whose products are important in migraine pathogenesis. However, these studies focus on single genes without analyzing how epigenetic modifications can affect complex signaling pathways. This narrative/hypothesis review aims to provide information on how the reactive oxygen and nitrogen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40890590
DOI: 10.1186/s10194-025-02114-z

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