Article
The role of HER-3 expression in the prediction of clinical outcome for advanced colorectal cancer patients receiving irinotecan and cetuximab.
The oncologist - 1 Jan 2011
Scartozzi Mario, Mandolesi Alessandra, Giampieri Riccardo, Bittoni Alessandro, Pierantoni Chiara, Zaniboni Alberto, Galizia Eva, Giustini Lucio, Silva Rosa Rita, Bisonni Renato, Berardi Rossana, Biscotti Tommasina, Biagetti Simona, Bearzi Italo, Cascinu Stefano
Abstract excerpt
Preclinical data suggested that, in the presence of human epidermal growth factor receptor (HER)-3-altered activation, colorectal cancer cells may escape anti-epidermal growth factor receptor (EGFR)-mediated cell death. HER-3 overexpression may then represent a key factor for resistance to anti-E...
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