Article
EGFR and HER3 mRNA expression levels predict distant metastases in locally advanced rectal cancer.
International journal of cancer - 15 Jun 2011
Ho-Pun-Cheung Alexandre, Assenat Eric, Bascoul-Mollevi Caroline, Bibeau Frédéric, Boissière-Michot Florence, Cellier Dominic, Azria David, Rouanet Philippe, Senesse Pierre, Ychou Marc, Lopez-Crapez Evelyne
Abstract excerpt
Aberrant activation of the HER signaling pathways plays a critical role in the invasive and metastatic potential of tumors. The aim of this study was to address whether, in rectal cancer, alterations of these pathways could have a value as prognostic factors to be used to identify patients who are at risk of distant metastases. Therefore, the mRNA expression of the four members of the HER family as well as the...
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