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Delineating the Requirement for the <i>Borrelia burgdorferi</i> Virulence Factor OspC in the Mammalian Host

19 May 2006

Abstract excerpt

We previously demonstrated that outer surface protein C (OspC) of Borrelia burgdorferi is essential for establishing mammalian infection. However, the role of OspC in mammalian infection is unknown. Here, we report experiments designed to distinguish between two models of OspC function in the mammalian host: (i) OspC fulfills an essential physiological role for growth and host adaptation or (ii) OspC provides a...

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PMID: 16714587
DOI: 10.1128/iai.00158-06

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