Article
Prior infection of pigs with a genotype 3 swine hepatitis E virus (HEV) protects against subsequent challenges with homologous and heterologous genotypes 3 and 4 human HEV.
Virus research - 1 Jul 2011
Sanford Brenton J, Dryman Barbara A, Huang Yao-Wei, Feagins Alicia R, Leroith Tanya, Meng Xiang-Jin
Abstract excerpt
Hepatitis E virus (HEV) is an important human pathogen. At least four recognized and two putative genotypes of mammalian HEV have been reported: genotypes 1 and 2 are restricted to humans whereas genotypes 3 and 4 are zoonotic. The current experimental vaccines are all based on a single strain of HEV, even though multiple genotypes of HEV are co-circulating in some countries and thus an individual may be exposed...
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