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Article

Endocrine Disruption of Brain Sexual Differentiation by Developmental PCB Exposure

29 Dec 2010

Abstract excerpt

In mammals, sexual differentiation of the hypothalamus occurs during prenatal and early postnatal development due in large part to sex differences in hormones. These early organizational processes are critically important for the attainment and maintenance of adult reproductive functions. We tested the hypothesis that perinatal exposure to polychlorinated biphenyls (PCBs) that disrupt hormonal pathways would...

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PMID: 21190954
DOI: 10.1210/en.2010-1103

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