Article
Prophage spontaneous activation promotes DNA release enhancing biofilm formation in Streptococcus pneumoniae.
PloS one - 20 Dec 2010
Carrolo Margarida, Frias Maria João, Pinto Francisco Rodrigues, Melo-Cristino José, Ramirez Mário
Abstract excerpt
Streptococcus pneumoniae (pneumococcus) is able to form biofilms in vivo and previous studies propose that pneumococcal biofilms play a relevant role both in colonization and infection. Additionally, pneumococci recovered from human infections are characterized by a high prevalence of lysogenic bacteriophages (phages) residing quiescently in their host chromosome. We investigated a possible link between lysogeny...
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