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Multiple holins contribute to extracellular DNA release in Pseudomonas aeruginosa biofilms.

Microbiology (Reading, England) - 1 Feb 2021

Hynen Amelia L, Lazenby James J, Savva George M, McCaughey Laura C, Turnbull Lynne, Nolan Laura M, Whitchurch Cynthia B

Abstract excerpt

Bacterial biofilms are composed of aggregates of cells encased within a matrix of extracellular polymeric substances (EPS). One key EPS component is extracellular DNA (eDNA), which acts as a 'glue', facilitating cell-cell and cell-substratum interactions. We have previously demonstrated that eDNA is produced in Pseudomonas aeruginosa biofilms via explosive cell lysis. This phenomenon involves a subset of the...

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Bacterial Proteins
Bacteriolysis
Biofilms
DNA, Bacterial
Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pseudomonas aeruginosa

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PMID: 33400641
DOI: 10.1099/mic.0.000990
PMCID: PMC8131026

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