Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer.

Anticancer research - 1 Dec 2010

Imai Hisao, Kaira Kyoichi, Oriuchi Noboru, Shimizu Kimihiro, Tominaga Hideyuki, Yanagitani Noriko, Sunaga Noriaki, Ishizuka Tamotsu, Nagamori Shushi, Promchan Kanyarat, Nakajima Takashi, Yamamoto Nobuyuki, Mori Masatomo, Kanai Yoshikatsu

Abstract excerpt

BACKGROUND: L-type amino acid transporter 1 (LAT1) is highly expressed in various human neoplasms. Antitumor activity of inhibiting LAT1 was analyzed in non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Expression of LAT1 mRNA in 54 lung cancer cell lines was examined by RT-PCR. An inhib...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids, Cyclic
Share to Antineoplastic Combined Chemotherapy Protocols

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung

Share to Cell Growth Processes

Share to Gefitinib

Share to Leucine

Share to Quinazolines

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 21187458

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21187458-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer.PMID 21187458Read ↗

Inhibition of the amino‐acid transporter LAT1 demonstrates anti‐neoplastic activity in medulloblastomaSemantic proximity Read ↗

BCAT1 decreases the sensitivity of cancer cells to cisplatin by regulating mTOR-mediated autophagy via branched-chain amino acid metabolismSemantic proximity Read ↗

Claudin-1 enhances chemoresistance of human lung adenocarcinoma A549 cells mediated by forming an amino acid barrierSemantic proximity Read ↗

LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cellsSemantic proximity Read ↗

<scp>L</scp>‐type amino acid transporter 1 as a potential molecular target in human astrocytic tumorsSemantic proximity Read ↗

A Beclin 1-targeting stapled peptide synergizes with erlotinib to potently inhibit proliferation of non-small-cell lung cancer cells.Semantic proximity Read ↗

Coccinic acid exhibits anti-tumor efficacy against NSCLC harboring EGFR L858R/T790M mutation via the EGFR/STAT3 pathway.Semantic proximity Read ↗

α-Lipoic acid-induced inhibition of proliferation and met phosphorylation in human non-small cell lung cancer cells.Semantic proximity Read ↗

Exploring monocarboxylate transporter inhibition for cancer treatmentSemantic proximity Read ↗

Survival Outcomes of Calcium Channel Blocker Therapy in Patients With Non-Small Cell Lung Cancer Treated With Epidermal Growth Factor Receptor Inhibitors: A Retrospective Study.Semantic proximity Read ↗

Choline Transporters in Human Lung Adenocarcinoma: Expression and Functional ImplicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.