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Article

MiR-886-3p Down Regulates CXCL12 (SDF1) Expression in Human Marrow Stromal Cells

13 Dec 2010

Abstract excerpt

Stromal Derived Factor 1 (SDF1 or CXCL12), is a chemokine known to be critical for the migration of cells in several tissue systems including the homing of the hematopoietic stem cell (HSC) to its niche in the bone marrow. A comparative analysis of miRNA expression profiles of two stromal cell lines, distinguishable by function and by CXCL12 expression (CXCL12+ and CXCL12-), revealed that the CXCL12- cells...

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PMID: 21179442
DOI: 10.1371/journal.pone.0014304

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