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Article

Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice.

PloS one - 13 Dec 2010

Jörs Simone, Grimm Christian, Becker Lars, Heller Stefan

Abstract excerpt

TRPML3, a member of the transient receptor potential (TRP) family, is an inwardly rectifying, non-selective Ca2+-permeable cation channel that is regulated by extracytosolic Na+ and H+ and can be activated by a variety of small molecules. The severe auditory and vestibular phenotype of the TRPML3(A419P) varitint-waddler mutation made this protein particularly interesting for inner ear biology. To elucidate the...

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Identifiers

PMID: 21179200
DOI: 10.1371/journal.pone.0014317
PMCID: PMC3001452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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