Article
Evaluating vaccinia virus cytokine co-expression in TLR GKO mice.
Immunology and cell biology - 1 Aug 2011
Sutherland Duncan B, Ranasinghe Charani, Regner Matthias, Phipps Simon, Matthaei Klaus I, Day Stephanie L, Ramshaw Ian A
Abstract excerpt
Using Toll-like receptor (TLR) and MyD88 gene knock-out (GKO) mice the effect of TLRs and MyD88 on virus replication, interferon (IFN)-β production, natural killer (NK) cell and CD8T cell responses were assessed following ectromelia virus (ECTV) and recombinant vaccinia virus (rVV) infection. The capacity for rVVs encoding cytokines to restore immune function in MyD88(-/-) mice was clearly demonstrated. Results...
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