Article
Vitamin D receptor gene methylation is associated with ethnicity, tuberculosis, and TaqI polymorphism.
Human immunology - 1 Mar 2011
Andraos Charlene, Koorsen Gerrit, Knight Julian C, Bornman Liza
Abstract excerpt
The Vitamin D receptor (VDR) gene encodes a transcription factor which, on activation by vitamin D, modulates diverse biologic processes, including calcium homeostasis and immune function. Genetic variation involving VDR shows striking differences in allele frequency between populations and has been associated with disease susceptibility, including tuberculosis and autoimmunity, although results have often been...
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