Article
Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study.
The Journal of infectious diseases - 1 Nov 2004
Bornman Liza, Campbell Sarah J, Fielding Katherine, Bah Boubacar, Sillah Jackson, Gustafson Per, Manneh Kebba, Lisse Ida, Allen Angela, Sirugo Giorgio, Sylla Aissatou, Aaby Peter, McAdam Keith P W J, Bah-Sow Oumou, Bennett Steve, Lienhardt Christian, Hill Adrian V S
Abstract excerpt
Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global...
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