Article
Familial thoracic aortic aneurysms and dissections: identification of a novel locus for stable aneurysms with a low risk for progression to aortic dissection.
Circulation. Cardiovascular genetics - 1 Feb 2011
Guo Dong-Chuan, Regalado Ellen S, Minn Charles, Tran-Fadulu Van, Coney Joshua, Cao Jiumei, Wang Min, Yu Robert K, Estrera Anthony L, Safi Hazim J, Shete Sanjay S, Milewicz Dianna M
Abstract excerpt
BACKGROUND: Thoracic aortic aneurysms leading to acute aortic dissections are the major diseases that affect the thoracic aorta. Approximately 20% of patients with thoracic aortic aneurysms and dissections (TAAD) have a family history of TAAD, and these patients present younger with more rapidly enlarging aneurysms than patients without a family history of aortic disease. METHODS AND RESULTS: A large family with...
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