Article
Enteric oxalate elimination is induced and oxalate is normalized in a mouse model of primary hyperoxaluria following intestinal colonization with Oxalobacter.
American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2011
Hatch Marguerite, Gjymishka Altin, Salido Eduardo C, Allison Milton J, Freel Robert W
Abstract excerpt
Oxalobacter colonization of rat intestine was previously shown to promote enteric oxalate secretion and elimination, leading to significant reductions in urinary oxalate excretion (Hatch et al. Kidney Int 69: 691-698, 2006). The main goal of the present study, using a mouse model of primary hyperoxaluria type 1 (PH1), was to test the hypothesis that colonization of the mouse gut by Oxalobacter formigenes could...
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