Article
Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations.
Cancer research - 15 Dec 2010
Okamoto Kunio, Okamoto Isamu, Okamoto Wataru, Tanaka Kaoru, Takezawa Ken, Kuwata Kiyoko, Yamaguchi Haruka, Nishio Kazuto, Nakagawa Kazuhiko
Abstract excerpt
The molecular mechanism by which epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) induce apoptosis in non-small cell-lung cancer (NSCLC) cells that are positive for activating mutations of the EGFR remains unclear. In this study, we report the effects of the EGFR-TKI gefitin...
Topics
- Apoptosis
- Apoptosis Regulatory Proteins
- Bcl-2-Like Protein 11
- Carcinoma, Non-Small-Cell Lung
- Cell Line, Tumor
- Down-Regulation
- ErbB Receptors
- Gefitinib
- Gene Knockdown Techniques
- Genes, erbB-1
- Humans
- Inhibitor of Apoptosis Proteins
- Lung Neoplasms
- Membrane Proteins