Heavy-chain class switch does not terminate somatic mutation.

doi:10.1084/jem.172.2.531

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Article

Heavy-chain class switch does not terminate somatic mutation.

The Journal of experimental medicine - 1 Aug 1990

Shan H, Shlomchik M, Weigert M

Abstract excerpt

We studied the H-chain class switch rearrangement in four groups of clonally related B cell hybridomas, to test the hypothesis that class switch terminates somatic mutation in a B cell. Using switch region-specific probes in Southern blot analysis individual mu-gamma switch rearrangement events c...

Topics

Animals
Antibodies, Monoclonal
Autoimmune Diseases
Blotting, Southern
Cell Line
DNA
Gene Rearrangement
Genes, Regulator
Genes, Switch
Immunoglobulin Heavy Chains
Immunoglobulin Switch Region
Liver
Mice
Mice, Mutant Strains
Mutation
Restriction Mapping

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