Activation of colicin M by the FkpA prolyl cis-trans isomerase/chaperone.

doi:10.1074/jbc.M110.165274

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Article

Activation of colicin M by the FkpA prolyl cis-trans isomerase/chaperone.

The Journal of biological chemistry - 25 Feb 2011

Helbig Stephanie, Patzer Silke I, Schiene-Fischer Cordelia, Zeth Kornelius, Braun Volkmar

Abstract excerpt

Colicin M (Cma) is specifically imported into the periplasm of Escherichia coli and kills the cells. Killing depends on the periplasmic peptidyl prolyl cis-trans isomerase/chaperone FkpA. To identify the Cma prolyl bonds targeted by FkpA, we replaced the 15 proline residues individually with alanine. Seven mutant proteins were fully active; Cma(P129A), Cma(P176A), and Cma(P260A) displayed 1%, and Cma(P107A)...

Topics

Colicins
Escherichia coli
Escherichia coli Proteins
Membrane Proteins
Mutation
Osmotic Pressure
Peptidylprolyl Isomerase
Periplasmic Proteins
Protein Folding

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Identifiers

PMID: 21149455
DOI: 10.1074/jbc.M110.165274
PMCID: PMC3057819

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