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Article

Protease-deficient DegP suppresses lethal effects of a mutant OmpC protein by its capture.

Journal of bacteriology - 1 Jan 2003

CastilloKeller Maria, Misra Rajeev

Abstract excerpt

The expression of assembly-defective outer membrane proteins can confer lethality if they are not degraded by envelope proteases. We report here that the expression of a mutant OmpC protein, OmpC(2Cys), which forms disulfide bonds in the periplasm due to the presence of two non-native cysteine residues, is lethal in cells lacking the major periplasmic protease, DegP. This lethality is not observed in dsbA strains...

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Identifiers

PMID: 12486051
DOI: 10.1128/JB.185.1.148-154.2003
PMCID: PMC141919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protease-deficient DegP suppresses lethal effects of a mutant OmpC protein by its capture.PMID 12486051Read ↗

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