Article
Structure of RavA MoxR AAA+ protein reveals the design principles of a molecular cage modulating the inducible lysine decarboxylase activity.
Proceedings of the National Academy of Sciences of the United States of America - 28 Dec 2010
El Bakkouri Majida, Gutsche Irina, Kanjee Usheer, Zhao Boyu, Yu Miao, Goret Gael, Schoehn Guy, Burmeister Wim P, Houry Walid A
Abstract excerpt
The MoxR family of AAA+ ATPases is widespread throughout bacteria and archaea but remains poorly characterized. We recently found that the Escherichia coli MoxR protein, RavA (Regulatory ATPase variant A), tightly interacts with the inducible lysine decarboxylase, LdcI/CadA, to form a unique cage-like structure. Here, we present the X-ray structure of RavA and show that the αβα and all-α subdomains in the RavA...
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