Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lost in Translation: Neuropsychiatric Drug Development

8 Dec 2010

Abstract excerpt

Recent studies have identified troubling method and practice lapses in neuropsychiatric drug developments. These problems have resulted in errors that are of sufficient magnitude to invalidate clinical trial data and interpretations. We identify two potential sources for these difficulties: investigators selectively choosing scientific practices for demonstrations of efficacy in human-testing phases of drug...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder and Treatment
Share to Schizophrenia research and treatment
Share to Treatment of Major Depression

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21148128
DOI: 10.1126/scitranslmed.3000446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lost in Translation: Neuropsychiatric Drug DevelopmentPMID 21148128Read ↗

Methods for Neuroscience Drug Development: Guidance on Standardization of the Process for Defining Clinical Outcome Strategies in Clinical TrialsSemantic proximity Read ↗

History repeating: A roadmap to address common problems in psychedelic scienceSemantic proximity Read ↗

Commentary on methods for addressing functional unblinding and mechanistic uncertainty in clinical trials of psychedelic-assisted treatmentsSemantic proximity Read ↗

Commentary on methods for addressing functional unblinding and mechanistic uncertainty in clinical trials of psychedelic-assisted treatmentsSemantic proximity Read ↗

Translating biological parameters into clinically useful diagnostic tests.Semantic proximity Read ↗

Animal models of depression in drug discovery: a historical perspective.Semantic proximity Read ↗

Cautionary Observations Concerning the Introduction of Psychophysiological Biomarkers into Neuropsychiatric PracticeSemantic proximity Read ↗

Current and future clinical trials for Alzheimer's disease: evolving ethical concerns.Semantic proximity Read ↗

The use of animal models in psychiatric research and treatment.Semantic proximity Read ↗

A collaborative approach to targeted treatment development for schizophrenia: a qualitative evaluation of the NIMH-MATRICS project.Semantic proximity Read ↗

A pragmatic reevaluation of the efficacy of nonhuman primate optogenetics for psychiatrySemantic proximity Read ↗

Blinding and Expectancy Confounds in Psychedelic Randomised Controlled TrialsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.