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Article

New insights into the cause of Parkinson's disease

1 Dec 1992

Abstract excerpt

Current concepts as to the cause of Parkinson's disease (PD) suggest an inherited predisposition to environmental or endogenous toxic agents. Study of the substantia nigra after death in PD has highlighted three major changes: (1) evidence of oxidative stress and depletion of reduced glutathione; (2) high levels of total iron, with reduced ferritin buffering; and (3) mitochondrial complex I deficiency. Which of...

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PMID: 1461374
DOI: 10.1212/wnl.42.12.2241

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