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Article

Reversible inhibition of endocytosis in cultured neurons from the Drosophila temperature-sensitive mutant shibirets1.

Journal of neurogenetics - 1 Apr 1990

Masur S K, Kim Y T, Wu C F

Abstract excerpt

The Drosophila mutant, shibirets1 (shits1), is paralyzed at restrictive temperatures (greater than 29 degrees C) by a reversible block in synaptic transmission. Heat pulses deplete synaptic vesicles in nerve terminals and inhibit endocytic internalization of plasma membrane in garland cells and oocytes. In dissociated cultures of larval central nervous system (CNS), a temperature-sensitive defect is also...

Topics

Animals
Axons
Calcium
Cells, Cultured
Drosophila melanogaster
Endocytosis
Horseradish Peroxidase
Microscopy, Electron
Mutation
Nervous System Physiological Phenomena
Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Temperature

Source

Identifiers

PMID: 2113575
DOI: 10.3109/01677069009107110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2113575-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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