Article
Efficacy and tolerability of first-line triple therapy with levofloxacin and amoxicillin plus esomeprazole or rabeprazole for the eradication of Helicobacter pylori infection and the effect of CYP2C19 genotype: a 1-week, randomized, open-label study in Chinese adults.
Clinical therapeutics - 1 Nov 2010
Pan Xiaolin, Li Yuqing, Qiu Yuping, Tang Qiyun, Qian Bingbing, Yao Linhua, Shi Ruihua, Zhang Guoxin
Abstract excerpt
BACKGROUND: First-line triple therapy with levofloxa- cin and amoxicillin plus a proton pump inhibitor has been reported to be effective and well tolerated in the eradication of Helicobacter pylori infection. Studies have reported that cytochrome P450 (CYP) 2C19 genotypes may affect the clinical efficacy of clarithromycinbased triple therapies, although there is only one report of such an effect with...
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