Phenotypic and genotypic analysis of Helicobacter pylori resistance patterns, molecular characteristics, and CYP2C19 polymorphisms in Nanjing: a retrospective cross-sectional study.

Abstract excerpt

Background: The continued rise in antibiotic resistance of Helicobacter pylori (H. pylori) poses a major challenge to clinical eradication therapy. The resistance patterns and phenotype-genotype concordance of H. pylori in the Nanjing region have not been systematically reported in recent years. Methods: Data from 7227 enrolled patients at Nanjing First Hospital (2018-2024) were retrospectively analyzed. Among...

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