Cloning of a cDNA encoding adenylosuccinate lyase by functional complementation in Escherichia coli.

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Article

Cloning of a cDNA encoding adenylosuccinate lyase by functional complementation in Escherichia coli.

The Journal of biological chemistry - 5 Jun 1990

Aimi J, Badylak J, Williams J, Chen Z D, Zalkin H, Dixon J E

Abstract excerpt

Adenylosuccinate lyase was cloned by functional complementation of an Escherichia coli purB mutant using an avian liver cDNA expression library. The derived amino acid sequence is homologous to the bacterial purB-encoded adenylosuccinate lyase which catalyzes the same two steps in purine biosynth...

Topics

Adenylosuccinate Lyase
Amino Acid Sequence
Animals
Bacillus subtilis
Base Sequence
Chickens
Cloning, Molecular
DNA
Escherichia coli
Humans
Lyases
Molecular Sequence Data
Mutation
Nucleic Acid Hybridization
Plasmids
Sequence Homology, Nucleic Acid
Transformation, Bacterial

Source

Open in PubMed

Identifiers

PMID: 2111814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2111814-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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