Article
Anticipation in familial hematologic malignancies.
Blood - 27 Jan 2011
Tegg Elizabeth M, Thomson Russell J, Stankovich Jim M, Banks Annette, Marsden Katherine A, Lowenthal Ray M, Foote Simon J, Dickinson Joanne L
Abstract excerpt
We describe a collection of 11 families with ≥ 2 generations of family members whose condition has been diagnosed as a hematologic malignancy. In 9 of these families there was a significant decrease in age at diagnosis in each subsequent generation (anticipation). The mean age at diagnosis in the first generation was 67.8 years, 57.1 years in the second, and 41.8 years in the third (P < .0002). This was confirmed...
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