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Article

The yeast vps class E mutants: the beginning of the molecular genetic analysis of multivesicular body biogenesis.

Molecular biology of the cell - 1 Dec 2010

Coonrod Emily M, Stevens Tom H

Abstract excerpt

In 1992, Raymond et al. published a compilation of the 41 yeast vacuolar protein sorting (vps) mutant groups and described a large class of mutants (class E vps mutants) that accumulated an exaggerated prevacuolar endosome-like compartment. Further analysis revealed that this "class E compartment" contained soluble vacuolar hydrolases, vacuolar membrane proteins, and Golgi membrane proteins unable to recycle back...

Topics

Endosomal Sorting Complexes Required for Transport
Endosomes
Golgi Apparatus
History, 20th Century
Multivesicular Bodies
Mutation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Vacuoles
Vesicular Transport Proteins

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Identifiers

PMID: 21115849
DOI: 10.1091/mbc.E09-07-0603
PMCID: PMC2993735

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