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Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance

14 Sept 2007

Abstract excerpt

Long-term allograft survival generally requires lifelong immunosuppression (IS). Rarely, recipients display spontaneous "operational tolerance" with stable graft function in the absence of IS. The lack of biological markers of this phenomenon precludes identification of potentially tolerant patients in which IS could be tapered and hinders the development of new tolerance-inducing strategies. The objective of...

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PMID: 17873064
DOI: 10.1073/pnas.0705834104

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