Article
The functional class evaluated in rheumatoid arthritis is associated with soluble TGF-β1 serum levels but not with G915C (Arg25Pro) TGF-β1 polymorphism.
Rheumatology international - 1 Feb 2012
Muñoz-Valle José Francisco, Torres-Carrillo Nora Magdalena, Guzmán-Guzmán Iris Paola, Torres-Carrillo Norma, Ruiz-Quezada Sandra Luz, Palafox-Sánchez Claudia Azucena, Rangel-Villalobos Héctor, Ramírez-Dueñas María Guadalupe, Parra-Rojas Isela, Fafutis-Morris Mary, Bastidas-Ramírez Blanca Estela, Pereira-Suárez Ana Laura
Abstract excerpt
The influence of genetic factors in rheumatoid arthritis (RA) has been described, including several cytokine genes such as transforming growth factor β (TGF-β) with regulatory effects on lymphocytes, dendritic cells, macrophages, chondrocytes, and osteoblasts, which are important in the RA pathogenesis. The G915C TGF-β1 polymorphism has been associated with soluble TGF-β1 (sTGF-β) serum levels. Thus, we studied...
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