Article
Membrane curvature during peroxisome fission requires Pex11.
The EMBO journal - 5 Jan 2011
Opaliński Łukasz, Kiel Jan A K W, Williams Chris, Veenhuis Marten, van der Klei Ida J
Abstract excerpt
Pex11 is a key player in peroxisome proliferation, but the molecular mechanisms of its function are still unknown. Here, we show that Pex11 contains a conserved sequence at the N-terminus that can adopt the structure of an amphipathic helix. Using Penicillium chrysogenum Pex11, we show that this amphipathic helix, termed Pex11-Amph, associates with liposomes in vitro. This interaction is especially evident when...
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