Article
Islet1 selectively promotes peripheral axon outgrowth in Rohon-Beard primary sensory neurons.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2011
Tanaka Hideomi, Nojima Yasuhiro, Shoji Wataru, Sato Miki, Nakayama Ryoko, Ohshima Toshio, Okamoto Hitoshi
Abstract excerpt
We isolated a novel zebrafish mutant, lullaby (llb), and showed that the llb locus encodes the zebrafish orthologue of isl1. Rohon-Beard (RB) primary sensory neurons are multipolar neurons that extend their central axons longitudinally within the spinal cord and also extend their peripheral axons under the skin. In llb embryos, the outgrowth of the peripheral axons of RB neurons was selectively impaired, which...
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