Prognostic and predictive value of epidermal growth factor receptor tyrosine kinase domain mutation status and gene copy number for adjuvant chemotherapy in non-small cell lung cancer.

doi:10.1097/JTO.0b013e3181fd83a4

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Article

Prognostic and predictive value of epidermal growth factor receptor tyrosine kinase domain mutation status and gene copy number for adjuvant chemotherapy in non-small cell lung cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jan 2011

Tsao Ming-Sound, Sakurada Akira, Ding Keyue, Aviel-Ronen Sarit, Ludkovski Olga, Liu Ni, Le Maître Aurélie, Gandara David, Johnson David H, Rigas James R, Seymour Lesley, Shepherd Frances A

Abstract excerpt

PURPOSE: Patients with non-small cell lung carcinoma with epidermal growth factor receptor (EGFR) mutations may have a more favorable prognosis and greater response to chemotherapy. The effect of EGFR mutation and gene copy on patients with early-stage non-small cell lung carcinoma receiving adjuvant chemotherapy has not been reported. PATIENTS AND METHODS: Tumor samples from NCIC Clinical Trials Group JBR.10, an...

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PMID: 21107284
DOI: 10.1097/JTO.0b013e3181fd83a4
PMCID: PMC3033998

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EGFR

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