Predictive biomarkers for response to EGFR-directed monoclonal antibodies for advanced squamous cell lung cancer.

doi:10.1093/annonc/mdy196

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Article

Predictive biomarkers for response to EGFR-directed monoclonal antibodies for advanced squamous cell lung cancer.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Aug 2018

Bonomi P D, Gandara D, Hirsch F R, Kerr K M, Obasaju C, Paz-Ares L, Bellomo C, Bradley J D, Bunn P A, Culligan M, Jett J R, Kim E S, Langer C J, Natale R B, Novello S, Pérol M, Ramalingam S S, Reck M, Reynolds C H, Smit E F, Socinski M A, Spigel D R, Vansteenkiste J F, Wakelee H, Thatcher N

Abstract excerpt

Background: Upregulated expression and aberrant activation of the epidermal growth-factor receptor (EGFR) are found in lung cancer, making EGFR a relevant target for non-small-cell lung cancer (NSCLC). Treatment with anti-EGFR monoclonal antibodies (mAbs) is associated with modest improvement in overall survival in patients with squamous cell lung cancer (SqCLC) who have a significant unmet need for effective...

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PMID: 29905778
DOI: 10.1093/annonc/mdy196
PMCID: PMC6128180

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EGFR

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