Article
Characterization of two substrains of Puumala virus that show phenotypes that are different from each other and from the original strain.
Journal of virology - 1 Feb 2011
Sundström Karin B, Stoltz Malin, Lagerqvist Nina, Lundkvist Åke, Nemirov Kirill, Klingström Jonas
Abstract excerpt
Hantaviruses, the causative agents of two emerging diseases, are negative-stranded RNA viruses with a tripartite genome. We isolated two substrains from a parental strain of Puumala hantavirus (PUUV-Pa), PUUV-small (PUUV-Sm) and PUUV-large (PUUV-La), named after their focus size when titrated. The two isolates were sequenced; this revealed differences at two positions in the nucleocapsid protein and two positions...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Chlorocebus aethiops
- Epithelial Cells
- Fibroblasts
- Humans
- Kidney
- Lung
- Molecular Sequence Data
- Mutation
- Nucleocapsid Proteins
- Phenotype
- Puumala virus