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Article

Altered <i>MEF2</i> isoforms in myotonic dystrophy and other neuromuscular disorders

22 Nov 2010

Abstract excerpt

Because of their central role in muscle development and maintenance, MEF2 family members represent excellent candidate effectors of the muscle pathology in myotonic dystrophy (DM). We investigated the expression and alternative splicing of all four MEF2 genes in muscle from neuromuscular disorder (NMD) patients, including DM1 and DM2. We observed MEF2A and MEF2C overexpression in all NMD muscle, including 12...

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PMID: 21104860
DOI: 10.1002/mus.21789

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