Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene Expression Analysis in Myotonic Dystrophy: Indications for a Common Molecular Pathogenic Pathway in DM1 and DM2

1 Jun 2006

Abstract excerpt

An RNA gain-of-function of expanded transcripts is the most accredited molecular mechanism for myotonic dystrophy type 1 (DM1) and 2 (DM2). To disclose molecular parallels and divergences in pathogenesis of both disorders, we compared the expression profile of muscle biopsies from DM1 and DM2 patients to controls. DM muscle tissues showed a reduction in the major skeletal muscle chloride channel (CLCN1) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Mitochondrial Function and Pathology
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17708420
DOI: 10.3727/000000006781510705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene Expression Analysis in Myotonic Dystrophy: Indications for a Common Molecular Pathogenic Pathway in DM1 and DM2PMID 17708420Read ↗

Myotonic Dystrophy Type 2: An Update on Clinical Aspects, Genetic and Pathomolecular MechanismSemantic proximity Read ↗

An Overview of Alternative Splicing Defects Implicated in Myotonic Dystrophy Type ISemantic proximity Read ↗

Pathogenic mechanisms of myotonic dystrophy.Semantic proximity Read ↗

The hallmarks of myotonic dystrophy type 1 muscle dysfunctionSemantic proximity Read ↗

MicroRNA-Based Therapeutic Perspectives in Myotonic DystrophySemantic proximity Read ↗

Clinical and molecular aspects of the myotonic dystrophies: A reviewSemantic proximity Read ↗

Myotonic dystrophy: is a narrow focus obscuring the rest of the field?Semantic proximity Read ↗

Distinct pathological signatures in human cellular models of myotonic dystrophy subtypes.Semantic proximity Read ↗

Clinical aspects, molecular pathomechanisms and management of myotonic dystrophies.Semantic proximity Read ↗

Myotonic dystrophySemantic proximity Read ↗

Overexpression of CUGBP1 in skeletal muscle from adult classic myotonic dystrophy type 1 but not from myotonic dystrophy type 2.Semantic proximity Read ↗

Myotonic Dystrophy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.