Article
Association analysis about HLA-DRB1, -DQB1 polymorphism and auto-antibodies against α(1)-adrenergic receptors in Chinese patients with essential hypertension.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Jan 2010
Sun Yanxiang, Zhu Feng, Wang Min, Ma Shihui, Liao Yuhua
Abstract excerpt
The auto-antibodies against α(1)-adrenergic receptors (α(1)-AAs) with agonist activity likes norepinephrine have been discovered in patients with essential hypertension but the mechanism of α(1)-AA production remains unclear. We supposed the α(1)-AAs be correlated to the HLA-DQB1 and DRB1 alleles. Three hundred ninety-six patients with essential hypertension (EH) and 224 normotensives were enrolled, and DNA...
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