Article
Correlation between HLA-DRB1, HLA-DQB1 polymorphism and autoantibodies against angiotensin AT(1) receptors in Chinese patients with essential hypertension.
Clinical cardiology - 1 May 2011
Zhu Feng, Sun Yanxiang, Wang Min, Ma Shihui, Chen Xiao, Cao Ailin, Chen Fen, Qiu Yan, Liao Yuhua
Abstract excerpt
BACKGROUND: The autoantibodies (AAs) against angiotensin AT(1) receptors (AT(1) -AAs) have been discovered in patients with preeclampsia, malignant hypertension, and essential hypertension (EH); however, the mechanism of AA production remains to be investigated. HYPOTHESIS: Polymorphisms of HLA-DRB1 or HLA-DQB1 are related to production of AAs in autoimmune diseases. We hypothesis that the polymorphisms of the...
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