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Izumiphenazines A−C: Isolation and Structure Elucidation of Phenazine Derivatives from <i>Streptomyces</i> sp. IFM 11204

23 Nov 2010

Abstract excerpt

Three new phenazine derivatives, named izumiphenazines A-C (1-3), and the known phenazine-1,6-dicarboxylic acid (4) were isolated from Streptomyces sp. IFM 11204. The structures of the isolated compounds were elucidated by means of spectroscopic methods including UV, IR, HRESIMS, and 1D and 2D NMR. Compounds 1-3 were evaluated for their activity in overcoming TRAIL (TNF-related apoptosis-inducing ligand)...

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PMID: 21090727
DOI: 10.1021/np100400t

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