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Article

Depletion of CXCR2 inhibits γ-secretase activity and amyloid-β production in a murine model of Alzheimer's disease.

Cytokine - 1 Feb 2011

Bakshi Pancham, Margenthaler Elaina, Reed Jon, Crawford Fiona, Mullan Michael

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder that leads to progressive cognitive decline. Recent studies from our group and others have suggested that certain G-protein coupled receptors (GPCRs) can influence the processing of the amyloid precursor protein (APP). Earlier, we demonstra...

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Source

Identifiers

PMID: 21084199
DOI: 10.1016/j.cyto.2010.10.008

Genes

CXCR2
APP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21084199-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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