Article
Q192R polymorphism of the paraoxonase-1 gene as a risk factor for obesity in Portuguese women.
European journal of endocrinology - 1 Feb 2011
Veiga Luísa, Silva-Nunes José, Melão Alice, Oliveira Ana, Duarte Leone, Brito Miguel
Abstract excerpt
INTRODUCTION: Obesity became a major public health problem as a result of its increasing prevalence worldwide. Paraoxonase-1 (PON1) is an esterase able to protect membranes and lipoproteins from oxidative modifications. At the PON1 gene, several polymorphisms in the promoter and coding regions have been identified. The aims of this study were i) to assess PON1 L55M and Q192R polymorphisms as a risk factor for...
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