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Article

Analysis of optineurin in frontotemporal lobar degeneration.

Neurobiology of aging - 1 Feb 2012

Rollinson Sara, Bennion Janis, Toulson Greg, Halliwell Nicola, Usher Suzanne, Snowden Julie, Richardson Anna, Neary David, Mann David, Pickering-Brown Stuart M

Abstract excerpt

Frontotemporal lobar degeneration (FTLD) can occur jointly with amyotrophic lateral sclerosis (ALS), and these 2 conditions share a genetic risk factor on chromosome 9. It has been reported that mutations in optineurin (OPTN) can cause ALS. Therefore, we sequenced OPTN in 371 FTLD cases but no mu...

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Identifiers

PMID: 21074902
DOI: 10.1016/j.neurobiolaging.2010.10.002

Genes

OPTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21074902-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Screening for OPTN mutations in amyotrophic lateral sclerosis in a mainly Caucasian population.Semantic proximity Read ↗

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