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Article

Environmental risk factors for inhibitor development in children with haemophilia A: a case-control study.

British journal of haematology - 1 Aug 2005

Santagostino Elena, Mancuso Maria Elisa, Rocino Angiola, Mancuso Giacomo, Mazzucconi Maria Gabriella, Tagliaferri Annarita, Messina Maria, Mannucci Pier Mannuccio

Abstract excerpt

This case-control study investigated the interactions between genetic and environmental factors and inhibitor development in 108 children with haemophilia A exclusively treated with recombinant factor VIII (FVIII). Sixty patients with inhibitors were compared with 48 inhibitor-free controls. Family history of inhibitors and null mutations in the FVIII gene were more prevalent in cases than in controls (20% vs....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16042693
DOI: 10.1111/j.1365-2141.2005.05605.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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