Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The genetic and clinical significance of MYCN gain as detected by FISH in neuroblastoma.

Pediatric surgery international - 1 Mar 2011

Souzaki Ryota, Tajiri Tatsuro, Teshiba Risa, Higashi Mayumi, Kinoshita Yoshiaki, Tanaka Sakura, Taguchi Tomoaki

Abstract excerpt

PURPOSE: MYCN amplification (MYCN-A) is a strong prognostic factor in neuroblastoma (NB). MYCN gain which is a low level of MYCN-A as determined by FISH. It is unclear whether the MYCN gain is the pre-status of MYCN-A. This study assessed the status of MYCN gene and chromosome 2p of MYCN-A, MYCN...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chi-Square Distribution
Share to Chromosomes, Human, Pair 2
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to N-Myc Proto-Oncogene Protein

Share to Neuroblastoma

Share to Oncogene Proteins

Share to Survival Rate

Source

Identifiers

PMID: 21046119
DOI: 10.1007/s00383-010-2781-4

Genes

MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21046119-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The genetic and clinical significance of MYCN gain as detected by FISH in neuroblastoma.PMID 21046119Read ↗

Copy number gain of MYCN gene is a recurrent genetic aberration and favorable prognostic factor in Chinese pediatric neuroblastoma patients.Semantic proximity Read ↗

Association of MYCN copy number with clinical features, tumor biology, and outcomes in neuroblastoma: A report from the Children's Oncology GroupSemantic proximity Read ↗

MYCN protein stability is a better prognostic indicator in neuroblastomaSemantic proximity Read ↗

MYCN Fish combined with immunohistochemistry is a more prognostic factor for neuroblastomaSemantic proximity Read ↗

Characterization of amplicons in neuroblastoma: high-resolution mapping using DNA microarrays, relationship with outcome, and identification of overexpressed genes.Semantic proximity Read ↗

MYCN amplification predicts poor prognosis based on interphase fluorescence in situ hybridization analysis of bone marrow cells in bone marrow metastases of neuroblastomaSemantic proximity Read ↗

MYCN-status in neuroblastoma: characteristics of tumours showing amplification, gain, and non-amplificationSemantic proximity Read ↗

Clinical evaluation of integrated panel testing by next-generation sequencing for somatic mutations in neuroblastomas with MYCN unamplification.Semantic proximity Read ↗

Application of the FISH method and high-density SNP arrays to assess genetic changes in neuroblastoma-research by one institute.Semantic proximity Read ↗

Single nucleotide polymorphism array analysis to predict clinical outcome in neuroblastoma patients.Semantic proximity Read ↗

High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: four cases of homozygous deletions of the CDKN2A gene.Semantic proximity Read ↗

A systematic review of circulating-free MYCN amplification status as a noninvasive and prominent prognostic and recurrence monitoring indicator for neuroblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.