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Article

Evaluation of six CTLA-4 polymorphisms in high-risk melanoma patients receiving adjuvant interferon therapy in the He13A/98 multicenter trial.

Journal of translational medicine - 3 Nov 2010

Gogas Helen, Dafni Urania, Koon Henry, Spyropoulou-Vlachou Maria, Metaxas Yannis, Buchbinder Elizabeth, Pectasides Eirini, Tsoutsos Dimosthenis, Polyzos Aristidis, Stratigos Alexandros, Markopoulos Christos, Panagiotou Petros, Fountzilas George, Castana Ourania, Skarlos Pantelis, Atkins Michael B, Kirkwood John M

Abstract excerpt

PURPOSE: Interferon is approved for adjuvant treatment of patients with stage IIb/III melanoma. The toxicity and uncertainty regarding survival benefits of interferon have qualified its acceptance, despite significant durable relapse prevention in a fraction of patients. Predictive biomarkers that would enable selection of patients for therapy would have a large impact upon clinical practice. Specific CTLA-4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21044351
DOI: 10.1186/1479-5876-8-108
PMCID: PMC2988721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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