Article
The regulatory element READ1 epistatically influences reading and language, with both deleterious and protective alleles.
Journal of medical genetics - 1 Mar 2016
Powers Natalie R, Eicher John D, Miller Laura L, Kong Yong, Smith Shelley D, Pennington Bruce F, Willcutt Erik G, Olson Richard K, Ring Susan M, Gruen Jeffrey R
Abstract excerpt
BACKGROUND: Reading disability (RD) and language impairment (LI) are heritable learning disabilities that obstruct acquisition and use of written and spoken language, respectively. We previously reported that two risk haplotypes, each in strong linkage disequilibrium (LD) with an allele of READ1, a polymorphic compound short tandem repeat within intron 2 of risk gene DCDC2, are associated with RD and LI....
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