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Article

Genome-wide identification of Streptococcus pneumoniae genes essential for bacterial replication during experimental meningitis.

Infection and immunity - 1 Jan 2011

Molzen T E, Burghout P, Bootsma H J, Brandt C T, van der Gaast-de Jongh Christa E, Eleveld M J, Verbeek M M, Frimodt-Møller N, Østergaard C, Hermans P W M

Abstract excerpt

Meningitis is the most serious of invasive infections caused by the Gram-positive bacterium Streptococcus pneumoniae. Vaccines protect only against a limited number of serotypes, and evolving bacterial resistance to antimicrobials impedes treatment. Further insight into the molecular pathogenesis of invasive pneumococcal disease is required in order to enable the development of new or adjunctive treatments and/or...

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PMID: 21041497
DOI: 10.1128/IAI.00631-10
PMCID: PMC3019918

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