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Article

Characterization of the A2AR-D2R interface: focus on the role of the C-terminal tail and the transmembrane helices.

Biochemical and biophysical research communications - 26 Nov 2010

Borroto-Escuela Dasiel O, Romero-Fernandez Wilber, Tarakanov Alexander O, Gómez-Soler Maricel, Corrales Fidel, Marcellino Daniel, Narvaez Manuel, Frankowska Malgorzata, Flajolet Marc, Heintz Nathaniel, Agnati Luigi F, Ciruela Francisco, Fuxe Kjell

Abstract excerpt

A single serine point mutation (S374A) in the adenosine A(2A) receptor (A(2A)R) C-terminal tail reduces A(2A)R-D(2)R heteromerization and prevents its allosteric modulation of the dopamine D(2) receptor (D(2)R). By means of site directed mutagenesis of the A(2A)R and synthetic transmembrane (TM) α-helix peptides of the D(2)R we further explored the role of electrostatic interactions and TM helix interactions of...

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PMID: 21040702
DOI: 10.1016/j.bbrc.2010.10.122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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